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KMID : 0386519960040020091
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Research Institute of Korean Medicone
1996 Volume.4 No. 2 p.91 ~ p.104
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Effects of Kyejibokryounghwan, Jeodangtang, Kyejibokryounghwan & Jeodangtangon on Intravascular Coagulation Induced by Endotoxin in Rats
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Abstract
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This study was perofrmed to prove the clinical effects of Kyejibokryoung hwan(KBH), Jeodangtang(JDT), Kyejibokryounghwan & Jeo-dangtang(KJT) by way of experimentalmethods.
The intravascular coagulation was induced by injection of endotoxin into the caudal vein of rats. And lipuidextracts of Kyejibokryoughwan, Jeodangtang, Kyejibokryounghwan & Jeodang-tang were administerd orally to the rats. Then the number of
platelets,
concentraiton of fibrinogen, FDP(fibrin-fibrinogen degradation products), prothrombin time and PTT(partial thromboplastin time) were measured.
@ES The results were obtained as follows:
@EN 1. The number of platelets was significantly increased in KBH and KJT-treated groups in comparison with the control group.
2. Fibrinogen was significantly increased in all sample groups as compared with the control group.
3. FDP was insignificantly decreased in all sample groups but have not significant.
4. Prothrombin time was significantly shortened in JDT and KJT-treated groups as compared with the control group.
5. PTT was significantly shortened in only KJT-treated groups as compared with the control group.
From the above results, it was concluded that Kyejibokryounghwan, Jeodang tang, Kyeibokyounghwan & Jeodangtang can be applied effectively in the disease of thrombosis.
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KEYWORD
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